s.a.k.jongkees(at)uu.nl

Department of Chemical Biology and Drug Discovery
Universiteitsweg 99
Utrecht 3584CG
Netherlands

©2016 by Seino Jongkees

About Us

The Jongkees group uses chemical and biological tools to conduct research at the interface of peptides and carbohydrates.

 

Research in our group is centred around genetic code reprogramming, bio-orthogonal chemistry, and high throughput in vitro peptide display. Using these cutting edge chemical and biochemical technologies, we aim to define a new class of ligands for interrogation and modulation of the proteins involved in carbohydrate biology. These small de novo macrocyclic peptides decorated with non-canonical functional groups have exemplary affinity and selectivity, and are applicable across very diverse targets. Research in the group is focused on development of new methods for library modification, including new non-canonical amino acids to incorporate by ribosomal translation and new bio-orthogonal reactions for modification following translation, as well as application of these technologies to discover new chemical entities for biological studies and drug development. Our research involves synthetic organic chemistry, analytical studies of new reactions, biochemical characterisation of interactions with proteins, and in vitro selection to discover new bioactive molecules. 

 

If you are interested in this research, please do not hesitate to make contact.

 

Our group is a part of the department of Chemical Biology and Drug Discovery at Utrecht University

Latest news

Dec 1, 2019

Welcome back to Rick, re-joining us for his Master's internship in Drug Innovation

Sep 1, 2019

Welcome to David, joining us for his Bachelor's internship from the Molecular Life Science program

Jul 30, 2019

Congratulations again to Leander, Minglong, Lieke, and Ryoji for their article being featured on the front cover of ACS Chemical Biology 
https://pubs.acs.org/toc/acbcct/14/8

Jun 26, 2019

Congratulations to Leander Goldbach, Minglong Liu, Lieke van Gijzel, and Ryoji Yoshisada for their publication on peptide conformations and binding in ACS Chemical Biology https://pubs.acs.org/doi/10.1021/acschembio.9b00290

Mar 27, 2019

Congratulations to Lemeng Chao for her review publication in Angewandte Chemie https://onlinelibrary.wiley.com/doi/full/10.1002/ange.201900055

Mar 7, 2019

Congratulations to former student Ryoji for winning third prize at the KNCV PAC symposium in Amsterdam for his poster presentation about his work in the group

Feb 4, 2019

Welcome to Rick, joining us for his Bachelors internship from the College of Pharmaceutical Sciences

Jan 21, 2019

Welcome to Julia, joining us for the minor internship of her Drug Innovation masters in a joint project with the virology department

Dec 1, 2018

Welcome to Miha, joining us for the major internship of his Drug Innovation masters

Oct 29, 2018

Welcome to Hao, joining us for a research project during his exchange here in Utrecht

Sep 4, 2018

Welcome to Lloyd, joining us for his Bachelors internship from the College of Pharmaceutical Sciences program

Jul 11, 2018

Welcome to Dejvid, joining us for a summer project

Feb 5, 2018

Welcome to Marinda, joining us for her Bachelors internship from the College of Pharmaceutical Sciences program

Dec 1, 2017

Welcome to Najoua, joining us for her Masters internship from the Drug Innovation program

Nov 15, 2017

Congratulations again to Ryoji and Lieke, with their article featured on the front cover of ChemBioChem https://doi.org/10.1002/cbic.201700601

Oct 26, 2017

Welcome to Wendy, joining us for an internship under the Erasmus+ programme from Glasgow

Oct 8, 2017

Congratulations to Ryoji and Lieke for having their paper on peptide studies and natural product mimicry accepted in ChemBioChem
 https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201700457

Jun 1, 2017

Welcome back to Vito, joining us for a PhD after completing his masters at TU-Eindhoven.

May 1, 2017

Now funded by European Union Marie Skłodowska-Curie fellowship - a greatly appreciated source of support.

Apr 24, 2017

Welcome to Danique, joining us from the chemistry department for a short internship.

Mar 17, 2017

Paper on Rapid discovery of potent and selective glycosidase-inhibiting de novo peptides published in Cell Chemical Biology https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30031-4

Feb 3, 2017

Welcome to Ryoji, joining us for an exchange year from Kyoto University.

Jan 30, 2017

Received Marie Curie grant, funding study on glycopeptide interactions with the immune recognition proteins called selectins.

Nov 26, 2016

Links section added.

Nov 1, 2016

Welcome to Avand, joining us for an internship from Leiden.

Oct 24, 2016

Paper on chemical glycosylation of macrocyclic peptide libraries accepted in Chemical Science 
https://pubs.rsc.org/en/content/articlepdf/2016/sc/c6sc04381j

Oct 10, 2016

Welcome to Minglong, starting his PhD.

Oct 5, 2016

Website finally live!

Dec 12, 2019

Funding received from National Centre for One Health to start an exciting collaborative project on "In-host adaptation in chronic fungal airway infections and development of new antifungals"

Jan 6, 2019

Welcome to Lin, joining us for her Bachelor's internship from the College of Pharmaceutical Sciences

Feb 2, 2019

Welcome to Lisa, joining us for her Bachelor's internship from the College of Pharmaceutical Sciences

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